Midatech has today announced encouraging headline results from a Phase I study at the University of California, San Francisco (‘UCSF’) in patients with the orphan condition, Diffuse Intrinsic Pontine Glioma (‘DIPG’) (the ‘UCSF study’ NCT03566199).
Having demonstrated that repeated delivery of MTX110 via micro-catheter using convection-enhanced delivery (‘CED’) is feasible and safe, improved overall patient survival data has determined a proposed dose range for adoption in a Phase II study to assess safety and efficacy that could potentially commence within a few months.
Although somewhat complicated by Secura Bio Inc.’s purported termination of its panobinostat licence agreement the patent’s now relatively limited life appears unlikely to significantly hinder prospective commercialisation. The valuation of £65.7m* that TPI awarded to Midatech in an assessment published on 10 September 2020 has the potential to be upgraded.
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