N4P has announced its appointment of Nanomerics Limited (‘Nanomerics’) to investigate the potential utility of Nuvec® in cancer therapy.
The project is designed to explore the role of its unique, non-viral adjuvant as a delivery system for DNA and small interfering RNA (‘siRNA’), with an initial aim to test a silica-based, delivery system in a proof of concept (‘POC’) preclinical tumour model (the ‘Oncology Programme’).
Not only could this represent a third commercial application for Nuvec® addressing a giant, unsatisfied and rapidly growing market, but also offer potential to be developed as a combination product capable of carrying an external nucleic acid load and an internal small molecule chemotherapeutic. Utilising Nanomerics’ advanced technologies, that are designed to address bioavailability challenges across a broad range of drugs, including low molecular weight hydrophobics, peptides, and nucleic acid based products, N4P seeks to demonstrate Nuvec‘s novel potential to become a delivery system for oncology therapeutics.
Taken together with its two existing programmes, feasibility work into oral applications and the ongoing technology transfer for Nuvec®’s manufacture, the next six months or so is likely to be pivotal for N4P as a greater understanding of its potential becomes more clearly established.
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