N4P has provided an update on its Nuvec® optimisation programme and proof of concept work involving COVID-19. Interestingly, delays imposed by the Pandemic lockdown presented an opportunity for the Group to explore a new initiative regarding Nuvec® ’s potential as an oral delivery system.
Research on the Group’s proprietary silica nanoparticles indicates that their unique spiky structure could provide a significant competitive advantage compared to existing, established routes of administration for vaccines (such as by injection) that are already in use.
In order to now demonstrate and verify this potential, N4P has now commissioned additional work by its contract research organisation (‘CRO’), Evotec Internation Gmbh (‘Evotec’), to undertake preliminary in vitro studies with a view to establishing that it can be optimised to transfect both murine intestinal cells and also human gastrointestinal mucosal/epithelial cells.
Such an outcome is likely to rapidly attract new interest from various ongoing COVID-19 and other vaccine development programmes that could benefit from oral administration.
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