Synairgen Plc (AIM:SNG) Update on LOXL2 Programme & Pharmaxis Collaboration

Synairgen (LSE: SNG), the respiratory drug discovery and development company, today announces an update to its collaboration agreement with Pharmaxis and the Lysyl Oxidase type 2 (LOXL2) programme. Following the successful completion of preclinical studies and the commencement of the Phase I clinical trial with its LOXL2 inhibitor programme, Pharmaxis and Synairgen have revised the terms of the collaboration.

Under the revised terms, Pharmaxis will take on full operational responsibilities for the programme, including the ongoing Phase I trial of the LOXL2 inhibitor PXS-5382. As a result of the combined work in the collaboration, Pharmaxis is concurrently developing a second LOXL2 inhibitor PXS-5338 (also in Phase I) which will expand partnering opportunities across multiple fibrotic conditions. The revised agreement fixes Synairgen’s interest across all fibrotic indications at cira 17% of all partnering proceeds.

Synairgen will have no further obligations to finance the development of the programme candidates, but will continue to provide technical support for the licensing process.

Pharmaxis will pay Synairgen £5 million cash in consideration for the revised terms.

Richard Marsden, Chief Executive Officer of Synairgen, said:

“Under the existing collaboration, Synairgen generated excellent data to support progression in the rare fibrotic lung disease idiopathic pulmonary fibrosis (IPF) and Pharmaxis has focused on the potentially larger indications of liver fibrosis (including non-alcoholic steatohepatitis (NASH)), cardiac fibrosis and kidney fibrosis. As we draw nearer to an optimal point for partnering the programme, it is more effective and should be more value enhancing to hand all control of the development to Pharmaxis to enable a single point of focus for multi-indication partnering discussions. Having previously been focused toward a lung-related partnering transaction, this change in terms enables Synairgen to benefit significantly from any licence(s) in the non-lung related fibrosis arena.”

Synairgen has been successfully collaborating with Pharmaxis in the research and development of a number of LOXL2 inhibitors over the past two years. These inhibitors have reduced fibrosis in Synairgen’s primary human cell models (that use cells from patients with fibrosis) and in in vivo models of fibrosis, clearly showing the potential of the LOXL2 inhibitors.

This collaboration demonstrates the value of Synairgen’s human disease biobank approach to drug discovery and development. Alongside progression of SNG001 into COPD, we will continue to assess new opportunities where we can add and create value.



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